Complement component C8 beta chain

BE0009051ProteinHumansC8B

Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis... It is acted on by 3 drugs in DrugBank.

Gene name
C8B
UniProtKB entry
P07358Swiss-Prot
Cellular location
Secreted
Residues / weight
591 residues · 66,947 Da
Also known as
Complement component 8 subunit beta

Resolves to

Protein
UniProtP07358UniProt nameCO8B_HUMAN
Gene
HGNCHGNC:1353NCBI Gene732GeneCardsC8B
Pharmacology
KEGGhsa:732
Structure
PDB3OJYPDB6H03PDB6H04
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Complement component C8 beta chain, how selective are they, and which programs against it are still in active trials?

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