Complement component C9

BE0009052ProteinHumansC9

Pore-forming component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell... It is acted on by 1 drug in DrugBank.

Gene name
C9
UniProtKB entry
P02748Swiss-Prot
Cellular location
Secreted
Residues / weight
559 residues · 63,173 Da

Resolves to

Protein
UniProtP02748UniProt nameCO9_HUMAN
Gene
HGNCHGNC:1358NCBI Gene735GeneCardsC9
Pharmacology
KEGGhsa:735
Structure
PDB5FMWPDB6DLWPDB6H03
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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20+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Complement component C9, how selective are they, and which programs against it are still in active trials?

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