Complement factor I

BE0009054ProteinHumansCFI

Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. It is acted on by 3 drugs in DrugBank.

Gene name
CFI
UniProtKB entry
P05156Swiss-Prot
Cellular location
Secreted, extracellular space
Residues / weight
583 residues · 65,750 Da
Also known as
3.4.21.45 · C3B/C4B inactivator · IF

Resolves to

Protein
UniProtP05156UniProt nameCFAI_HUMAN
Gene
HGNCHGNC:5394NCBI Gene3426GeneCardsCFI
Pharmacology
KEGGhsa:3426
Structure
PDB2XRCPDB5O32
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Complement factor I, how selective are they, and which programs against it are still in active trials?

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