Haptoglobin-related protein
Details
- Name
- Haptoglobin-related protein
- Kind
- protein
- Synonyms
- Not Available
- Gene Name
- HPR
- UniProtKB Entry
- P00739Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0049826|Haptoglobin-related protein MSDLGAVISLLLWGRQLFALYSGNDVTDISDDRFPKPPEIANGYVEHLFRYQCKNYYRLR TEGDGVYTLNDKKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAK MVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVL HPNYHQVDIGLIKLKQKVLVNERVMPICLPSKNYAEVGRVGYVSGWGQSDNFKLTDHLKY VMLPVADQYDCITHYEGSTCPKWKAPKSPVGVQPILNEHTFCVGMSKYQEDTCYGDAGSA FAVHDLEEDTWYAAGILSFDKSCAVAEYGVYVKVTSIQHWVQKTIAEN
- Number of residues
- 348
- Molecular Weight
- 39029.345
- Theoretical pI
- Not Available
- GO Classification
- Functionsserine-type endopeptidase activityComponentsextracellular space
- General Function
- Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron
- Specific Function
- Hemoglobin binding
- Pfam Domain Function
- Trypsin (PF00089)
- Signal Regions
- 1-18
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0049827|Haptoglobin-related protein (HPR) ATGAGTGACCTGGGAGCTGTCATTTCCCTCCTGCTCTGGGGACGACAGCTTTTTGCACTG TACTCAGGCAATGATGTCACGGATATTTCAGATGACCGCTTCCCGAAGCCCCCTGAGATT GCAAATGGCTATGTGGAGCACTTGTTTCGCTACCAGTGTAAGAACTACTACAGACTGCGC ACAGAAGGAGATGGAGTATACACCTTAAATGATAAGAAGCAGTGGATAAATAAGGCTGTT GGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAGAATCCGGCAAACCCA GTGCAGCGGATCCTGGGTGGACACCTGGATGCCAAAGGCAGCTTTCCCTGGCAGGCTAAG ATGGTTTCCCACCATAATCTCACCACAGGGGCCACGCTGATCAATGAACAATGGCTGCTG ACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACAGCGAAAGACATTGCC CCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATTGAGAAGGTGGTTCTA CACCCTAACTACCACCAGGTAGATATTGGGCTCATCAAACTCAAACAGAAGGTGCTTGTT AATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGAATTATGCAGAAGTAGGGCGTGTG GGTTACGTGTCTGGCTGGGGACAAAGTGACAACTTTAAACTTACTGACCATCTGAAGTAT GTCATGCTGCCTGTGGCTGACCAATACGATTGCATAACGCATTATGAAGGCAGCACATGC CCCAAATGGAAGGCACCGAAGAGCCCTGTAGGGGTGCAGCCCATACTGAACGAACACACC TTCTGTGTCGGCATGTCTAAGTACCAGGAAGACACCTGCTATGGCGATGCGGGCAGTGCC TTTGCCGTTCACGACCTGGAGGAGGACACCTGGTACGCGGCTGGGATCCTAAGCTTTGAT AAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACTTCCATCCAGCACTGG GTTCAGAAGACCATAGCTGAGAACTAA
- Chromosome Location
- 16
- Locus
- 16q22.2
- External Identifiers
Resource Link UniProtKB ID P00739 UniProtKB Entry Name HPTR_HUMAN GeneCard ID HPR HGNC ID HGNC:5156 KEGG ID hsa:3250 NCBI Gene ID 3250 - General References
- Bensi G, Raugei G, Klefenz H, Cortese R: Structure and expression of the human haptoglobin locus. EMBO J. 1985 Jan;4(1):119-26. [Article]
- Maeda N: Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element. J Biol Chem. 1985 Jun 10;260(11):6698-709. [Article]
- Erickson LM, Kim HS, Maeda N: Junctions between genes in the haptoglobin gene cluster of primates. Genomics. 1992 Dec;14(4):948-58. [Article]
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- Tabak S, Lev A, Valansi C, Aker O, Shalitin C: Transcriptionally active haptoglobin-related (Hpr) gene in hepatoma G2 and leukemia molt-4 cells. DNA Cell Biol. 1996 Nov;15(11):1001-7. [Article]
- Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. Genomics. 1999 Sep 15;60(3):295-308. [Article]
- Nielsen MJ, Petersen SV, Jacobsen C, Oxvig C, Rees D, Moller HJ, Moestrup SK: Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein. Blood. 2006 Oct 15;108(8):2846-9. Epub 2006 Jun 15. [Article]
- Harrington JM, Nishanova T, Pena SR, Hess M, Scelsi CL, Widener J, Hajduk SL: A retained secretory signal peptide mediates high density lipoprotein (HDL) assembly and function of haptoglobin-related protein. J Biol Chem. 2014 Sep 5;289(36):24811-20. doi: 10.1074/jbc.M114.567578. Epub 2014 Jul 17. [Article]