Kallistatin

BE0009067ProteinHumansSERPINA4

Inhibits human amidolytic and kininogenase activities of tissue kallikrein. It is acted on by 3 drugs in DrugBank.

Gene name
SERPINA4
UniProtKB entry
P29622Swiss-Prot
Cellular location
Secreted
Residues / weight
427 residues · 48,542 Da
Also known as
Kallikrein inhibitor · KST · Peptidase inhibitor 4 · PI-4 · PI4

Resolves to

Protein
UniProtP29622UniProt nameKAIN_HUMAN
Gene
HGNCHGNC:8948NCBI Gene5267GeneCardsSERPINA4
Pharmacology
KEGGhsa:5267
Structure
PDB6F02PDB6F4UPDB6F4V
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Kallistatin, how selective are they, and which programs against it are still in active trials?

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