Complement component C8 alpha chain

BE0009072ProteinHumansC8A

Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis... It is acted on by 2 drugs in DrugBank.

Gene name
C8A
UniProtKB entry
P07357Swiss-Prot
Cellular location
Secreted
Residues / weight
584 residues · 65,163 Da
Also known as
Complement component 8 subunit alpha

Resolves to

Protein
UniProtP07357UniProt nameCO8A_HUMAN
Gene
HGNCHGNC:1352NCBI Gene731GeneCardsC8A
Pharmacology
KEGGhsa:731
Structure
PDB2QOSPDB2QQHPDB2RD7
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Complement component C8 alpha chain, how selective are they, and which programs against it are still in active trials?

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