Ficolin-3

BE0009076ProteinHumansFCN3

Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the... It is acted on by 2 drugs in DrugBank.

Gene name
FCN3
UniProtKB entry
O75636Swiss-Prot
Cellular location
Secreted
Residues / weight
299 residues · 32,903 Da
Also known as
Collagen/fibrinogen domain-containing lectin 3 p35 · Collagen/fibrinogen domain-containing protein 3 · FCNH · H-ficolin · HAKA1

Resolves to

Protein
UniProtO75636UniProt nameFCN3_HUMAN
Gene
HGNCHGNC:3625NCBI Gene8547GeneCardsFCN3
Pharmacology
KEGGhsa:8547
Structure
PDB2J5ZPDB2J60PDB2J64
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Ficolin-3, how selective are they, and which programs against it are still in active trials?

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