Serine/arginine-rich splicing factor 1

BE0009139ProteinHumansSRSF1

Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. It is acted on by 1 drug in DrugBank.

Gene name
SRSF1
UniProtKB entry
Q07955Swiss-Prot
Cellular location
Chromosome
Residues / weight
248 residues · 27,744 Da
Also known as
Alternative-splicing factor 1 · ASF · ASF-1 · pre-mRNA-splicing factor SF2, P33 subunit · SF2

Resolves to

Protein
UniProtQ07955UniProt nameSRSF1_HUMAN
Gene
HGNCHGNC:10780NCBI Gene6426GeneCardsSRSF1
Pharmacology
KEGGhsa:6426
Structure
PDB1X4APDB2M7SPDB2M8D
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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43+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/arginine-rich splicing factor 1, how selective are they, and which programs against it are still in active trials?

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