G protein-coupled receptor 12

BE0009153ProteinHumansGPR12

Brain-specific G protein-coupled receptor involved in regulating diverse physiological processes including neurite outgrowth, meiotic arrest, and lipid and carbohydrate metabolism (By similarity). It is acted on by 3 drugs in DrugBank.

Gene name
GPR12
UniProtKB entry
P47775Swiss-Prot
Cellular location
Cell membrane
Residues / weight
334 residues · 36,730 Da

Resolves to

Protein
UniProtP47775UniProt nameGPR12_HUMAN
Gene
HGNCHGNC:4466NCBI Gene2835GeneCardsGPR12
Pharmacology
IUPHAR/GtoPdb86KEGGhsa:2835
Structure
PDB7Y3G
Drugs

What you can answer from here — as of June 19, 2026

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on G protein-coupled receptor 12, how selective are they, and which programs against it are still in active trials?

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