N-acylethanolamine-hydrolyzing acid amidase

BE0009156ProteinHumansNAAA

Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine (PubMed:15655246, PubMed:17980170, PubMed:18793752, PubMed:22825852, PubMed:30301806). It is acted on by 3 drugs in DrugBank.

Gene name
NAAA
UniProtKB entry
Q02083Swiss-Prot
Cellular location
Lysosome
Residues / weight
359 residues · 40,066 Da
Also known as
3.5.1.60 · Acid ceramidase-like protein · Acylsphingosine deacylase NAAA · ASAH-like protein · ASAHL

Resolves to

Protein
UniProtQ02083UniProt nameNAAA_HUMAN
Gene
HGNCHGNC:736NCBI Gene27163GeneCardsNAAA
Pharmacology
IUPHAR/GtoPdb1402KEGGhsa:27163
Structure
PDB6DXWPDB6DXX
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on N-acylethanolamine-hydrolyzing acid amidase, how selective are they, and which programs against it are still in active trials?

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