Somatostatin receptor type 4
Details
- Name
- Somatostatin receptor type 4
- Kind
- protein
- Synonyms
- SS-4-R
- SS4-R
- SS4R
- SST4
- Gene Name
- SSTR4
- UniProtKB Entry
- P31391Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0051548|Somatostatin receptor type 4 MSAPSTLPPGGEEGLGTAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLV GLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRHWPFGSVLCR AVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLP IAIFADTRPARGGQAVACNLQWPHPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRA VALRAGWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILS YANSCANPILYGFLSDNFRRFFQRVLCLRCCLLEGAGGAEEEPLDYYATALKSKGGAGCM CPPLPCQQEALQPEPGRKRIPLTRTTTF
- Number of residues
- 388
- Molecular Weight
- 42002.245
- Theoretical pI
- Not Available
- GO Classification
- ProcessesG protein-coupled receptor signaling pathway / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway / negative regulation of cell population proliferation / neuropeptide signaling pathway / positive regulation of arachidonic acid secretion / positive regulation of ERK1 and ERK2 cascade
- General Function
- Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells
- Specific Function
- neuropeptide binding
- Pfam Domain Function
- 7tm_1 (PF00001)
- Signal Regions
- Not Available
- Transmembrane Regions
- 47-73 84-104 121-142 162-185 209-232 261-280 292-314
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0051549|Somatostatin receptor type 4 (SSTR4) ATGAGCGCCCCCTCGACGCTGCCCCCCGGGGGCGAGGAAGGGCTGGGGACGGCCTGGCCC TCTGCAGCCAATGCCAGTAGCGCTCCGGCGGAGGCGGAGGAGGCGGTGGCGGGGCCCGGG GACGCGCGGGCGGCGGGCATGGTCGCTATCCAGTGCATCTACGCGCTGGTGTGCCTGGTG GGGCTGGTGGGCAACGCCCTGGTCATCTTCGTGATCCTTCGCTACGCCAAGATGAAGACG GCTACCAACATCTACCTGCTCAACCTGGCCGTAGCCGACGAGCTCTTCATGCTGAGCGTG CCCTTCGTGGCCTCGTCGGCCGCCCTGCGCCACTGGCCCTTCGGCTCCGTGCTGTGCCGC GCGGTGCTCAGCGTCGACGGCCTCAACATGTTCACCAGCGTCTTCTGTCTCACCGTGCTC AGCGTGGACCGCTACGTGGCCGTGGTGCACCCTCTGCGCGCGGCGACCTACCGGCGGCCC AGCGTGGCCAAGCTCATCAACCTGGGCGTGTGGCTGGCATCCCTGTTGGTCACTCTCCCC ATCGCCATCTTCGCAGACACCAGACCGGCTCGCGGCGGCCAGGCCGTGGCCTGCAACCTG CAGTGGCCACACCCGGCCTGGTCGGCAGTCTTCGTGGTCTACACTTTCCTGCTGGGCTTC CTGCTGCCCGTGCTGGCCATTGGCCTGTGCTACCTGCTCATCGTGGGCAAGATGCGCGCC GTGGCCCTGCGCGCTGGCTGGCAGCAGCGCAGGCGCTCGGAGAAGAAAATCACCAGGCTG GTGCTGATGGTCGTGGTCGTCTTTGTGCTCTGCTGGATGCCTTTCTACGTGGTGCAGCTG CTGAACCTCTTCGTGACCAGCCTTGATGCCACCGTCAACCACGTGTCCCTTATCCTTAGC TATGCCAACAGCTGCGCCAACCCCATTCTCTATGGCTTCCTCTCCGACAACTTCCGCCGA TTCTTCCAGCGGGTTCTCTGCCTGCGCTGCTGCCTCCTGGAAGGTGCTGGAGGTGCTGAG GAGGAGCCCCTGGACTACTATGCCACTGCTCTCAAGAGCAAAGGTGGGGCAGGGTGCATG TGCCCCCCACTCCCCTGCCAGCAGGAAGCCCTGCAACCAGAACCCGGCCGCAAGCGCATC CCCCTCACCAGGACCACCACCTTCTGA
- Chromosome Location
- 20
- Locus
- 20p11.21
- External Identifiers
Resource Link UniProtKB ID P31391 UniProtKB Entry Name SSR4_HUMAN GeneCard ID SSTR4 HGNC ID HGNC:11333 PDB ID(s) 7XMS, 7XMT KEGG ID hsa:6754 IUPHAR/Guide To Pharmacology ID 358 NCBI Gene ID 6754 - General References
- Xu Y, Song J, Bruno JF, Berelowitz M: Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4. Biochem Biophys Res Commun. 1993 Jun 15;193(2):648-52. [Article]
- Rohrer L, Raulf F, Bruns C, Buettner R, Hofstaedter F, Schule R: Cloning and characterization of a fourth human somatostatin receptor. Proc Natl Acad Sci U S A. 1993 May 1;90(9):4196-200. [Article]
- Yamada Y, Kagimoto S, Kubota A, Yasuda K, Masuda K, Someya Y, Ihara Y, Li Q, Imura H, Seino S, et al.: Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype. Biochem Biophys Res Commun. 1993 Sep 15;195(2):844-52. [Article]
- Demchyshyn LL, Srikant CB, Sunahara RK, Kent G, Seeman P, Van Tol HH, Panetta R, Patel YC, Niznik HB: Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20. Mol Pharmacol. 1993 Jun;43(6):894-901. [Article]
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- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Lutetium Lu 177 dotatate approved, investigational yes target agonist Details Somatostatin approved, investigational yes target agonist Details