Nucleotide-binding oligomerization domain-containing protein 2

BE0009323ProteinHumansNOD2

Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and plays an important role in gastrointestinal immunity (PubMed:12514169, PubMed:12527755, PubMed:12626759, PubMed:15044951, PubMed:15998797, PubMed:27283905, PubMed:27748583, PubMed:31649195). It is acted on by 4 drugs in DrugBank.

Gene name
NOD2
UniProtKB entry
Q9HC29Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,040 residues · 115,282 Da
Also known as
CARD15 · Caspase recruitment domain-containing protein 15 · Inflammatory bowel disease protein 1

Resolves to

Protein
UniProtQ9HC29UniProt nameNOD2_HUMAN
Gene
HGNCHGNC:5331NCBI Gene64127GeneCardsNOD2
Pharmacology
IUPHAR/GtoPdb1763KEGGhsa:64127
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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21GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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41+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nucleotide-binding oligomerization domain-containing protein 2, how selective are they, and which programs against it are still in active trials?

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