A disintegrin and metalloproteinase with thrombospondin motifs 13

BE0009336ProteinHumansADAMTS13

Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation. It is acted on by 4 drugs in DrugBank.

Gene name
ADAMTS13
UniProtKB entry
Q76LX8Swiss-Prot
Cellular location
Secreted
Residues / weight
1,427 residues · 153,603 Da
Also known as
3.4.24.87 · ADAM-TS 13 · ADAM-TS13 · ADAMTS-13 · C9orf8

Resolves to

Protein
UniProtQ76LX8UniProt nameATS13_HUMAN
Gene
HGNCHGNC:1366NCBI Gene11093GeneCardsADAMTS13
Pharmacology
KEGGhsa:11093
Structure
PDB3GHMPDB3GHNPDB3VN4
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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7Clinical trialsTrials of drugs acting on it, by phase and status
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20GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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44+ReferencesStructured and connected to the statements they support
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Which approved drugs act on A disintegrin and metalloproteinase with thrombospondin motifs 13, how selective are they, and which programs against it are still in active trials?

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