Splicing factor 3B subunit 1

BE0009359ProteinHumansSF3B1

Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:12234937, PubMed:27720643, PubMed:32494006, PubMed:34822310, PubMed:36104565). It is acted on by 2 drugs in DrugBank.

Gene name
SF3B1
UniProtKB entry
O75533Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,304 residues · 145,829 Da
Also known as
Pre-mRNA-splicing factor SF3b 155 kDa subunit · SAP 155 · SAP155 · SF3b155 · Spliceosome-associated protein 155

Resolves to

Protein
UniProtO75533UniProt nameSF3B1_HUMAN
Gene
HGNCHGNC:10768NCBI Gene23451GeneCardsSF3B1
Pharmacology
KEGGhsa:23451
Structure
PDB2F9DPDB2F9JPDB2FHO
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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19GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Splicing factor 3B subunit 1, and which indications are they being tested in?

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