Sodium/myo-inositol cotransporter

BE0009368ProteinHumansSLC5A3

Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity). It is acted on by 1 drug in DrugBank.

Gene name
SLC5A3
UniProtKB entry
P53794Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
718 residues · 79,663 Da
Also known as
Na(+)/myo-inositol cotransporter · SMIT1 · Sodium/myo-inositol transporter 1 · Solute carrier family 5 member 3

Resolves to

Protein
UniProtP53794UniProt nameSC5A3_HUMAN
Gene
HGNCHGNC:11038NCBI Gene6526GeneCardsSLC5A3
Pharmacology
KEGGhsa:6526
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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5+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sodium/myo-inositol cotransporter, how selective are they, and which programs against it are still in active trials?

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