Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

BE0009596ProteinHumansPDE1C

Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:29860631, PubMed:8557689). It is acted on by 2 drugs in DrugBank.

Gene name
PDE1C
UniProtKB entry
Q14123Swiss-Prot
Cellular location
Lysosome
Residues / weight
709 residues · 80,760 Da
Also known as
3.1.4.17 · Cam-PDE 1C · Hcam3

Resolves to

Protein
UniProtQ14123UniProt namePDE1C_HUMAN
Gene
HGNCHGNC:8776NCBI Gene5137GeneCardsPDE1C
Pharmacology
IUPHAR/GtoPdb1296KEGGhsa:5137
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C, and which indications are they being tested in?

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