Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

BE0009597ProteinHumansPDE6A

Catalytic alpha subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade.

Gene name
PDE6A
UniProtKB entry
P16499Swiss-Prot
Cellular location
Photoreceptor outer segment membrane
Residues / weight
860 residues · 99,547 Da
Also known as
3.1.4.35 · GMP-PDE alpha · PDE V-B1 · PDEA

Resolves to

Protein
UniProtP16499UniProt namePDE6A_HUMAN
Gene
HGNCHGNC:8785NCBI Gene5145GeneCardsPDE6A
Pharmacology
IUPHAR/GtoPdb1312KEGGhsa:5145

What you can answer from here — as of September 03, 2024

4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha, and which indications are they being tested in?

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