Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta

BE0009598ProteinHumansPDE6B

Catalytic beta subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade.

Gene name
PDE6B
UniProtKB entry
P35913Swiss-Prot
Cellular location
Photoreceptor outer segment membrane
Residues / weight
854 residues · 98,335 Da
Also known as
3.1.4.35 · GMP-PDE beta · PDEB

Resolves to

Protein
UniProtP35913UniProt namePDE6B_HUMAN
Gene
HGNCHGNC:8786NCBI Gene5158GeneCardsPDE6B
Pharmacology
KEGGhsa:5158

What you can answer from here — as of September 03, 2024

1Clinical trialTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta, and which indications are they being tested in?

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