Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

BE0009599ProteinHumansPDE6C

Catalytic alpha subunit of the cone-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP as part of the phototransduction cascade.

Gene name
PDE6C
UniProtKB entry
P51160Swiss-Prot
Cellular location
Photoreceptor outer segment membrane
Residues / weight
858 residues · 99,146 Da
Also known as
3.1.4.35 · cGMP phosphodiesterase 6C · PDEA2

Resolves to

Protein
UniProtP51160UniProt namePDE6C_HUMAN
Gene
HGNCHGNC:8787NCBI Gene5146GeneCardsPDE6C
Pharmacology
IUPHAR/GtoPdb1314KEGGhsa:5146
Structure
PDB3JWQPDB3JWRPDB5E8F

What you can answer from here — as of September 03, 2024

3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha', and which indications are they being tested in?

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