Cyclic AMP-dependent transcription factor ATF-2

BE0009602ProteinHumansATF2

Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response (PubMed:11932306, PubMed:15105425, PubMed:15916964, PubMed:22304920, PubMed:2529117). It is acted on by 1 drug in DrugBank.

Gene name
ATF2
UniProtKB entry
P15336Swiss-Prot
Cellular location
Nucleus
Residues / weight
505 residues · 54,537 Da
Also known as
Activating transcription factor 2 · cAMP response element-binding protein CRE-BP1 · cAMP-dependent transcription factor ATF-2 · cAMP-responsive element-binding protein 2 · CREB-2

Resolves to

Protein
UniProtP15336UniProt nameATF2_HUMAN
Gene
HGNCHGNC:784NCBI Gene1386GeneCardsATF2
Pharmacology
KEGGhsa:1386
Structure
PDB1BHIPDB1T2KPDB4H36
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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53GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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32+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Cyclic AMP-dependent transcription factor ATF-2, and which indications are they being tested in?

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