Voltage-dependent R-type calcium channel subunit alpha-1E

BE0009609ProteinHumansCACNA1E

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells (PubMed:30343943). It is acted on by 2 drugs in DrugBank.

Gene name
CACNA1E
UniProtKB entry
Q15878Swiss-Prot
Cellular location
Membrane
Residues / weight
2,313 residues · 261,729 Da
Also known as
BII · Brain calcium channel II · CACH6 · CACNL1A6 · Calcium channel, L type, alpha-1 polypeptide, isoform 6

Resolves to

Protein
UniProtQ15878UniProt nameCAC1E_HUMAN
Gene
HGNCHGNC:1392NCBI Gene777GeneCardsCACNA1E
Pharmacology
IUPHAR/GtoPdb534KEGGhsa:777
Structure
PDB3BXLPDB7XLQPDB7YG5
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Voltage-dependent R-type calcium channel subunit alpha-1E, how selective are they, and which programs against it are still in active trials?

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