Insulin-like growth factor-binding protein 1

BE0009658ProteinHumansIGFBP1

Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in... It is acted on by 1 drug in DrugBank.

Gene name
IGFBP1
UniProtKB entry
P08833Swiss-Prot
Cellular location
Secreted
Residues / weight
259 residues · 27,903 Da
Also known as
IBP-1 · IBP1 · IGF-binding protein 1 · IGFBP-1 · Placental protein 12

Resolves to

Protein
UniProtP08833UniProt nameIBP1_HUMAN
Gene
HGNCHGNC:5469NCBI Gene3484GeneCardsIGFBP1
Pharmacology
KEGGhsa:3484
Structure
PDB1ZT3PDB1ZT5PDB2DSQ
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
1GO termFunction, process and component, as structured annotations
Sign in
2Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
22+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Insulin-like growth factor-binding protein 1, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In