Insulin-like growth factor-binding protein 2

BE0009659ProteinHumansIGFBP2

Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type... It is acted on by 1 drug in DrugBank.

Gene name
IGFBP2
UniProtKB entry
P18065Swiss-Prot
Cellular location
Secreted
Residues / weight
325 residues · 34,814 Da
Also known as
BP2 · IBP-2 · IBP2 · IGF-binding protein 2 · IGFBP-2

Resolves to

Protein
UniProtP18065UniProt nameIBP2_HUMAN
Gene
HGNCHGNC:5471NCBI Gene3485GeneCardsIGFBP2
Pharmacology
KEGGhsa:3485
Structure
PDB2H7T
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Insulin-like growth factor-binding protein 2, how selective are they, and which programs against it are still in active trials?

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