Insulin-like growth factor-binding protein 4

BE0009660ProteinHumansIGFBP4

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. It is acted on by 1 drug in DrugBank.

Gene name
IGFBP4
UniProtKB entry
P22692Swiss-Prot
Cellular location
Secreted
Residues / weight
258 residues · 27,934 Da
Also known as
IBP-4 · IBP4 · IGF-binding protein 4 · IGFBP-4

Resolves to

Protein
UniProtP22692UniProt nameIBP4_HUMAN
Gene
HGNCHGNC:5473NCBI Gene3487GeneCardsIGFBP4
Pharmacology
KEGGhsa:3487
Structure
PDB1WQJPDB2DSPPDB2DSQ
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Insulin-like growth factor-binding protein 4, how selective are they, and which programs against it are still in active trials?

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