Insulin-like growth factor-binding protein 5

BE0009661ProteinHumansIGFBP5

Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18930415, PubMed:7683690). It is acted on by 1 drug in DrugBank.

Gene name
IGFBP5
UniProtKB entry
P24593Swiss-Prot
Cellular location
Secreted
Residues / weight
272 residues · 30,570 Da
Also known as
IBP-5 · IBP5 · IGF-binding protein 5 · IGFBP-5

Resolves to

Protein
UniProtP24593UniProt nameIBP5_HUMAN
Gene
HGNCHGNC:5474NCBI Gene3488GeneCardsIGFBP5
Pharmacology
KEGGhsa:3488
Structure
PDB1BOEPDB1H59PDB7UFG
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Insulin-like growth factor-binding protein 5, how selective are they, and which programs against it are still in active trials?

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