Insulin-like growth factor-binding protein 6

BE0009662ProteinHumansIGFBP6

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. It is acted on by 1 drug in DrugBank.

Gene name
IGFBP6
UniProtKB entry
P24592Swiss-Prot
Cellular location
Secreted
Residues / weight
240 residues · 25,322 Da
Also known as
IBP-6 · IBP6 · IGF-binding protein 6 · IGFBP-6

Resolves to

Protein
UniProtP24592UniProt nameIBP6_HUMAN
Gene
HGNCHGNC:5475NCBI Gene3489GeneCardsIGFBP6
Pharmacology
KEGGhsa:3489
Structure
PDB1RMJPDB2JM2
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Insulin-like growth factor-binding protein 6, how selective are they, and which programs against it are still in active trials?

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