Synaptic vesicular amine transporter

BE0009675ProteinMouseSlc18a2

Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. It is acted on by 2 drugs in DrugBank.

Gene name
Slc18a2
UniProtKB entry
Q8BRU6Swiss-Prot
Cellular location
Cytoplasmic vesicle membrane
Residues / weight
517 residues · 55,753 Da
Also known as
Monoamine transporter · Solute carrier family 18 member 2 · VAT2 · Vesicular amine transporter 2 · Vesicular monoamine transporter 2

Resolves to

Protein
UniProtQ8BRU6UniProt nameVMAT2_MOUSE
Gene
NCBI Gene214084
Pharmacology
KEGGmmu:214084
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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35GO termsFunction, process and component, as structured annotations
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5+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Synaptic vesicular amine transporter, how selective are they, and which programs against it are still in active trials?

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