B-cell antigen receptor complex-associated protein beta chain

BE0009680ProteinHumansCD79B

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. It is acted on by 1 drug in DrugBank.

Gene name
CD79B
UniProtKB entry
P40259Swiss-Prot
Cellular location
Cell membrane
Residues / weight
229 residues · 26,048 Da
Also known as
B-cell-specific glycoprotein B29 · B29 · Ig-beta · IGB · Immunoglobulin-associated B29 protein

Resolves to

Protein
UniProtP40259UniProt nameCD79B_HUMAN
Gene
HGNCHGNC:1699NCBI Gene974GeneCardsCD79B
Pharmacology
KEGGhsa:974
Structure
PDB3KG5PDB7WSOPDB7WSP
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7Clinical trialsTrials of drugs acting on it, by phase and status
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on B-cell antigen receptor complex-associated protein beta chain, how selective are they, and which programs against it are still in active trials?

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