POU domain, class 2, transcription factor 1

BE0009712ProteinHumansPOU2F1

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. It is acted on by 1 drug in DrugBank.

Gene name
POU2F1
UniProtKB entry
P14859Swiss-Prot
Cellular location
Nucleus
Residues / weight
743 residues · 76,471 Da
Also known as
NF-A1 · Oct-1 · OCT1 · Octamer-binding protein 1 · Octamer-binding transcription factor 1

Resolves to

Protein
UniProtP14859UniProt namePO2F1_HUMAN
Gene
HGNCHGNC:9212NCBI Gene5451GeneCardsPOU2F1
Pharmacology
KEGGhsa:5451
Structure
PDB1CQTPDB1E3OPDB1GT0
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which approved drugs act on POU domain, class 2, transcription factor 1, how selective are they, and which programs against it are still in active trials?

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