Cathepsin L-like proteinase
Details
- Name
- Cathepsin L-like proteinase
- Kind
- protein
- Synonyms
- 3.4.22.-
- Gene Name
- Cat-1
- UniProtKB Entry
- Q24940Swiss-Prot
- Organism
- Fasciola hepatica
- NCBI Taxonomy ID
- 6192
- Amino acid sequence
>lcl|BSEQ0052094|Cathepsin L-like proteinase MRLFILAVLTVGVLGSNDDLWHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDL GLVTYTLGLNQFTDMTFEEFKAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRESGYV TEVKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENA YQYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAA VAVDVESDFMMYRSGIYQSQTCSPLRVNHAVLAVGYGTQGGTDYWIVKNSWGTYWGERGY IRMARNRGNMCGIASLASLPMVARFP
- Number of residues
- 326
- Molecular Weight
- 36896.305
- Theoretical pI
- Not Available
- GO Classification
- Functionscysteine-type endopeptidase activity / endopeptidase activityProcessesproteolysisComponentsextracellular region
- General Function
- Thiol protease. Probably involved in interaction with host tissues. Displays a similar activity to that of papain. Has high activity on Z-Phe-Arg-NHMec, but no activity on Z-Arg-NHMec.
- Specific Function
- cysteine-type endopeptidase activity
- Pfam Domain Function
- Signal Regions
- 1-15
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
- Not Available
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q24940 UniProtKB Entry Name CATLL_FASHE PDB ID(s) 2O6X - General References
- Wijffels GL, Panaccio M, Salvatore L, Wilson L, Walker ID, Spithill TW: The secreted cathepsin L-like proteinases of the trematode, Fasciola hepatica, contain 3-hydroxyproline residues. Biochem J. 1994 May 1;299 ( Pt 3):781-90. doi: 10.1042/bj2990781. [Article]
Associated Data
- Drug Relations
- Not Available