NAD-dependent protein deacetylase sirtuin-2

BE0009759ProteinHumansSIRT2

NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors (PubMed:12620231, PubMed:16648462, PubMed:18249187, PubMed:18332217, PubMed:18995842, PubMed:20543840, PubMed:20587414, PubMed:21081649, PubMed:21726808, PubMed:21949390, PubMed:22014574, PubMed:22771473, PubMed:23468428,... It is acted on by 1 drug in DrugBank.

Gene name
SIRT2
UniProtKB entry
Q8IXJ6Swiss-Prot
Cellular location
Nucleus
Residues / weight
389 residues · 43,182 Da
Also known as
2.3.1.286 · NAD-dependent protein deacylase sirtuin-2 · NAD-dependent protein defatty-acylase sirtuin-2 · Regulatory protein SIR2 homolog 2 · SIR2-like protein 2

Resolves to

Protein
UniProtQ8IXJ6UniProt nameSIR2_HUMAN
Gene
HGNCHGNC:10886NCBI Gene22933GeneCardsSIRT2
Pharmacology
IUPHAR/GtoPdb2708KEGGhsa:22933
Structure
PDB1J8FPDB3ZGOPDB3ZGV
Drugs

What you can answer from here — as of September 16, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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20GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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59+ReferencesStructured and connected to the statements they support
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Which compounds in development act on NAD-dependent protein deacetylase sirtuin-2, and which indications are they being tested in?

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