Prohibitin 1

BE0009786ProteinHumansPHB1

Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). It is acted on by 2 drugs in DrugBank.

Gene name
PHB1
UniProtKB entry
P35232Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
272 residues · 29,804 Da
Also known as
PHB

Resolves to

Protein
UniProtP35232UniProt namePHB1_HUMAN
Gene
HGNCHGNC:8912NCBI Gene5245GeneCardsPHB1
Pharmacology
KEGGhsa:5245
Structure
PDB8RRHPDB9O6SPDB9O6T
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Prohibitin 1, and which indications are they being tested in?

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