ABC multidrug transporter MDR2
Details
- Name
- ABC multidrug transporter MDR2
- Kind
- protein
- Synonyms
- Multidrug resistance protein 2
- Gene Name
- MDR2
- UniProtKB Entry
- A0A059JJ46Swiss-Prot
- Organism
- Trichophyton interdigitale (strain MR816)
- NCBI Taxonomy ID
- 1215338
- Amino acid sequence
>lcl|BSEQ0052180|ABC multidrug transporter MDR2 MVEVSEKPNTQDDGVSKQENRNPASSSSSTSDKEKVAKKGNSDATKSSTPEDLDAQLAHL PEHEREILKQQLFIPDAKATYGTLFRYATRNDMIFLAIVSLASIAAGAALPLFTVLFGSL AGTFRDIALHRITYDEFNSILTRNSLYFVYLGIAQFILLYVSTVGFIYVGEHITQKIRAK YLHAILRQNIGFFDKLGAGEVTTRITADTNLIQDGISEKVGLTLTALSTFFSAFIIGYVR YWKLALICSSTIVAMILVMGGISRFVVKSGRMTLVSYGEGGTVAEEVISSIRNATAFGTQ EKLARQYEVHLKEARKWGRRLQMMLGIMFGSMMAIMYSNYGLGFWMGSRFLVGGETDLSA IVNILLAIVIGSFSIGNVAPNTQAFASAISAGAKIFSTIDRVSAIDPGSDEGDTIENVEG TIEFRGIKHIYPSRPEVVVMEDINLVVPKGKTTALVGPSGSGKSTVVGLLERFYNPVSGS VLLDGRDIKTLNLRWLRQQISLVSQEPTLFGTTIFENIRLGLIGSPMENESEEQIKERIV SAAKEANAHDFIMGLPDGYATDVGQRGFLLSGGQKQRIAIARAIVSDPKILLLDEATSAL DTKSEGVVQAALDAASRGRTTIVIAHRLSTIKSADNIVVIVGGRIAEQGTHDELVDKKGT YLQLVEAQKINEERGEESEDEAVLEKEKEISRQISVPAKSVNSGKYPDEDVEANLGRIDT KKSLSSVILSQKRSQEKETEYSLGTLIRFIAGFNKPERLIMLCGFFFAVLSGAGQPVQSV FFAKGITTLSLPPSLYGKLREDANFWSLMFLMLGLVQLVTQSAQGVIFAICSESLIYRAR SKSFRAMLRQDIAFFDLPENSTGALTSFLSTETKHLSGVSGATLGTILMVSTTLIVALTV ALAFGWKLALVCISTVPVLLLCGFYRFWILAQFQTRAKKAYESSASYACEATSSIRTVAS LTREQGVMEIYEGQLNDQAKKSLRSVAKSSLLYAASQSFSFFCLALGFWYGGGLLGKGEY NAFQFFLCISCVIFGSQSAGIVFSFSPDMGKAKSAAADFKRLFDRVPTIDIESPDGEKLE TVEGTIEFRDVHFRYPTRPEQPVLRGLNLTVKPGQYIALVGPSGCGKSTTIALVERFYDT LSGGVYIDGKDISRLNVNSYRSHLALVSQEPTLYQGTIRDNVLLGVDRDDVPDEQVFAAC KAANIYDFIMSLPDGFGTVVGSKGSMLSGGQKQRIAIARALIRDPKVLLLDEATSALDSE SEKVVQAALDAAAKGRTTIAVAHRLSTIQKADIIYVFDQGRIVESGTHHELLQNKGRYYE LVHMQSLEKTQ
- Number of residues
- 1331
- Molecular Weight
- 145278.17
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / ATPase activity / ATPase-coupled transmembrane transporter activityComponentsintegral component of membrane / plasma membrane
- General Function
- Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds, including terbinafine, 4-nitroquinoline N-oxide, and ethidium bromide (PubMed:16849730). May play a role in pathogenicity (PubMed:19141731).
- Specific Function
- ABC-type transporter activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 93-113 147-167 219-239 242-262 325-345 358-378 762-782 810-830 884-904 910-930 995-1015 1025-1045
- Cellular Location
- Cell membrane
- Gene sequence
- Not Available
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID A0A059JJ46 UniProtKB Entry Name MDR2_TRIIM - General References
- Persinoti GF, Martinez DA, Li W, Dogen A, Billmyre RB, Averette A, Goldberg JM, Shea T, Young S, Zeng Q, Oliver BG, Barton R, Metin B, Hilmioglu-Polat S, Ilkit M, Graser Y, Martinez-Rossi NM, White TC, Heitman J, Cuomo CA: Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum. Genetics. 2018 Apr;208(4):1657-1669. doi: 10.1534/genetics.117.300573. Epub 2018 Feb 21. [Article]
- Fachin AL, Ferreira-Nozawa MS, Maccheroni W Jr, Martinez-Rossi NM: Role of the ABC transporter TruMDR2 in terbinafine, 4-nitroquinoline N-oxide and ethidium bromide susceptibility in Trichophyton rubrum. J Med Microbiol. 2006 Aug;55(Pt 8):1093-9. doi: 10.1099/jmm.0.46522-0. [Article]
- Paiao FG, Segato F, Cursino-Santos JR, Peres NT, Martinez-Rossi NM: Analysis of Trichophyton rubrum gene expression in response to cytotoxic drugs. FEMS Microbiol Lett. 2007 Jun;271(2):180-6. doi: 10.1111/j.1574-6968.2007.00710.x. Epub 2007 Apr 10. [Article]
- Maranhao FC, Paiao FG, Fachin AL, Martinez-Rossi NM: Membrane transporter proteins are involved in Trichophyton rubrum pathogenesis. J Med Microbiol. 2009 Feb;58(Pt 2):163-8. doi: 10.1099/jmm.0.002907-0. [Article]
- Martins MP, Franceschini ACC, Jacob TR, Rossi A, Martinez-Rossi NM: Compensatory expression of multidrug-resistance genes encoding ABC transporters in dermatophytes. J Med Microbiol. 2016 Jul;65(7):605-610. doi: 10.1099/jmm.0.000268. Epub 2016 Apr 26. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Terbinafine approved, investigational, vet_approved unknown transporter substrate Details