ABC multidrug transporter MDR2

BE0009791ProteinTrichophyton interdigitale (strain MR816)MDR2

Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds, including terbinafine, 4-nitroquinoline N-oxide, and ethidium bromide (PubMed:16849730). It is acted on by 1 drug in DrugBank.

Gene name
MDR2
UniProtKB entry
A0A059JJ46Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,331 residues · 145,278 Da
Also known as
Multidrug resistance protein 2

Resolves to

Protein
UniProtA0A059JJ46UniProt nameMDR2_TRIIM
Drugs

What you can answer from here — as of December 04, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on ABC multidrug transporter MDR2, how selective are they, and which programs against it are still in active trials?

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