Nectin-4

BE0009798ProteinHumansNECTIN4

Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. It is acted on by 1 drug in DrugBank.

Gene name
NECTIN4
UniProtKB entry
Q96NY8Swiss-Prot
Cellular location
Cell membrane
Residues / weight
510 residues · 55,454 Da
Also known as
Ig superfamily receptor LNIR · LNIR · Nectin cell adhesion molecule 4 · Poliovirus receptor-related protein 4 · PRR4

Resolves to

Protein
UniProtQ96NY8UniProt nameNECT4_HUMAN
Gene
HGNCHGNC:19688NCBI Gene81607GeneCardsNECTIN4
Pharmacology
IUPHAR/GtoPdb3112KEGGhsa:81607
Structure
PDB4FRWPDB4GJTPDB4JJH
Drugs

What you can answer from here — as of December 20, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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8GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nectin-4, how selective are they, and which programs against it are still in active trials?

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