Outer membrane protein OprM

BE0009804ProteinPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)oprM

The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance (PubMed:10889211, PubMed:25901994, PubMed:30944318, PubMed:33009415, PubMed:8226684). It is acted on by 1 drug in DrugBank.

Gene name
oprM
UniProtKB entry
Q51487Swiss-Prot
Cellular location
Cell outer membrane
Residues / weight
485 residues · 52,598 Da
Also known as
oprK

Resolves to

Protein
UniProtQ51487UniProt nameOPRM_PSEAE
Gene
NCBI Gene877851
Pharmacology
KEGGpae:PA0427
Structure
PDB1WP1PDB3D5KPDB4Y1K
Drugs

What you can answer from here — as of December 24, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Outer membrane protein OprM, how selective are they, and which programs against it are still in active trials?

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