Equilibrative nucleobase transporter 1

Details

Name

Equilibrative nucleobase transporter 1

Kind

protein

Synonyms

• ENBT1
• Protein FOAP-13
• Solute carrier family 43 member 3

Gene Name

SLC43A3

UniProtKB Entry

Q8NBI5Swiss-Prot

Organism

Humans

NCBI Taxonomy ID

9606

Amino acid sequence

>lcl|BSEQ0052205|Equilibrative nucleobase transporter 1
MAGQGLPLHVATLLTGLLECLGFAGVLFGWPSLVFVFKNEDYFKDLCGPDAGPIGNATGQ
ADCKAQDERFSLIFTLGSFMNNFMTFPTGYIFDRFKTTVARLIAIFFYTTATLIIAFTSA
GSAVLLFLAMPMLTIGGILFLITNLQIGNLFGQHRSTIITLYNGAFDSSSAVFLIIKLLY
EKGISLRASFIFISVCSTWHVARTFLLMPRGHIPYPLPPNYSYGLCPGNGTTKEEKETAE
HENRELQSKEFLSAKEETPGAGQKQELRSFWSYAFSRRFAWHLVWLSVIQLWHYLFIGTL
NSLLTNMAGGDMARVSTYTNAFAFTQFGVLCAPWNGLLMDRLKQKYQKEARKTGSSTLAV
ALCSTVPSLALTSLLCLGFALCASVPILPLQYLTFILQVISRSFLYGSNAAFLTLAFPSE
HFGKLFGLVMALSAVVSLLQFPIFTLIKGSLQNDPFYVNVMFMLAILLTFFHPFLVYREC
RTWKESPSAIA

Number of residues

491

Molecular Weight

54528.23

Theoretical pI

Not Available

GO Classification

Functions

adenine transmembrane transporter activity / fatty acid transmembrane transporter activity / guanine transmembrane transporter activity / xenobiotic transmembrane transporter activity

Processes

hypoxanthine transport

Components

basolateral plasma membrane

General Function

Sodium-independent purine-selective nucleobase transporter which mediates the equilibrative transport of extracellular purine nucleobases such as adenine, guanine and hypoxanthine (PubMed:26455426, PubMed:32339528). May regulate fatty acid (FA) transport in adipocytes, acting as a positive regulator of FA efflux and as a negative regulator of FA uptake (By similarity)

Specific Function

adenine transmembrane transporter activity

Pfam Domain Function

Not Available

Signal Regions

Not Available

Transmembrane Regions

17-37 72-92 102-122 123-143 156-176 188-208 279-299 319-339 356-376 396-418 427-447 456-476

Cellular Location

Basolateral cell membrane

Gene sequence

>lcl|BSEQ0052206|Solute carrier family 43 member 3 (SLC43A3)
ATGGCGGGCCAGGGCCTGCCCCTGCACGTGGCCACACTGCTGACTGGGCTGCTGGAATGC
CTGGGCTTTGCTGGCGTCCTCTTTGGCTGGCCTTCACTAGTGTTTGTCTTCAAGAATGAA
GATTACTTTAAGGATCTGTGTGGACCAGATGCTGGGCCGATTGGCAATGCCACAGGGCAG
GCTGACTGCAAAGCCCAGGATGAGAGGTTCTCACTCATCTTCACCCTGGGGTCCTTCATG
AACAACTTCATGACATTCCCCACTGGCTACATCTTTGACCGGTTCAAGACCACCGTGGCA
CGCCTCATAGCCATATTTTTCTACACCACCGCCACACTCATCATAGCCTTCACCTCTGCA
GGCTCAGCCGTGCTGCTCTTCCTGGCCATGCCAATGCTCACCATTGGGGGAATCCTGTTT
CTCATCACCAACCTGCAGATTGGGAACCTATTTGGCCAACACCGTTCGACCATCATCACT
CTGTACAATGGAGCATTTGACTCTTCCTCGGCAGTCTTCCTTATTATTAAGCTTCTTTAT
GAAAAAGGCATCAGCCTCAGGGCCTCCTTCATCTTCATCTCTGTCTGCAGTACCTGGCAT
GTAGCACGCACTTTCCTCCTGATGCCCCGGGGGCACATCCCATACCCACTGCCCCCCAAC
TACAGCTATGGCCTGTGCCCTGGGAATGGCACCACAAAGGAAGAGAAGGAAACAGCTGAG
CATGAAAACAGGGAGCTACAGTCAAAGGAGTTCCTTTCAGCGAAGGAAGAGACCCCAGGG
GCAGGGCAGAAGCAGGAACTCCGCTCCTTCTGGAGCTACGCTTTCTCTCGGCGCTTTGCC
TGGCACCTGGTGTGGCTGTCTGTGATACAGTTGTGGCACTACCTCTTCATTGGCACTCTC
AACTCCTTGCTGACCAACATGGCCGGTGGGGACATGGCACGAGTCAGCACCTACACAAAT
GCCTTTGCCTTCACTCAGTTCGGAGTGCTGTGTGCCCCCTGGAATGGCCTGCTCATGGAC
CGGCTTAAACAGAAGTACCAGAAGGAAGCAAGAAAGACAGGTTCCTCCACTTTGGCGGTG
GCCCTCTGCTCGACGGTGCCTTCGCTGGCCCTGACATCCCTGCTGTGCCTGGGCTTCGCC
CTCTGTGCCTCAGTCCCCATCCTCCCTCTCCAGTACCTCACCTTCATCCTGCAAGTGATC
AGCCGCTCCTTCCTCTATGGGAGCAACGCGGCCTTCCTCACCCTTGCTTTCCCTTCAGAG
CACTTTGGCAAGCTCTTTGGGCTGGTGATGGCCTTGTCGGCTGTGGTGTCTCTGCTCCAG
TTCCCCATCTTCACCCTCATCAAAGGCTCCCTTCAGAATGACCCATTTTACGTGAATGTG
ATGTTCATGCTTGCCATTCTTCTGACATTCTTCCACCCCTTTCTGGTATATCGGGAATGC
CGTACTTGGAAAGAAAGTCCCTCTGCAATTGCATAG

Chromosome Location

11

Locus

11q12.1

External Identifiers

Resource	Link
UniProtKB ID	Q8NBI5
UniProtKB Entry Name	S43A3_HUMAN
GeneCard ID	SLC43A3
HGNC ID	HGNC:17466
KEGG ID	hsa:29015
NCBI Gene ID	29015

General References

1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
2. Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. DNA Res. 2005;12(2):117-26. [Article]
3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [Article]
4. Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [Article]
5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
6. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [Article]
7. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. [Article]
8. Zhou H, Di Palma S, Preisinger C, Peng M, Polat AN, Heck AJ, Mohammed S: Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res. 2013 Jan 4;12(1):260-71. doi: 10.1021/pr300630k. Epub 2012 Dec 18. [Article]

Associated Data

Drug Relations

Drug	Drug group	Pharmacological action?	Type	Actions	Details
Azathioprine	approved	unknown	transporter	substrate	Details