RNA-directed RNA polymerase catalytic subunit

BE0009866ProteinInfluenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)PB1

RNA-dependent RNA polymerase which is responsible for replication and transcription of virus RNA segments. It is acted on by 1 drug in DrugBank.

Gene name
PB1
UniProtKB entry
Q809M3Swiss-Prot
Cellular location
Host nucleus
Residues / weight
757 residues · 86,420 Da
Also known as
2.7.7.48 · PB1 · Polymerase basic protein 1 · RNA-directed RNA polymerase subunit P1

Resolves to

Protein
UniProtQ809M3UniProt nameRDRP_I01A0
Drugs

What you can answer from here — as of March 08, 2020

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on RNA-directed RNA polymerase catalytic subunit, how selective are they, and which programs against it are still in active trials?

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