Long-chain fatty acid transport protein 2

BE0009868ProteinHumansSLC27A2

Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (PubMed:10198260, PubMed:10749848, PubMed:11980911, PubMed:20530735, PubMed:22022213, PubMed:24269233). It is acted on by 1 drug in DrugBank.

Gene name
SLC27A2
UniProtKB entry
O14975Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
620 residues · 70,312 Da
Also known as
ACSVL1 · Arachidonate--CoA ligase · FACVL1 · FATP-2 · FATP2

Resolves to

Protein
UniProtO14975UniProt nameS27A2_HUMAN
Gene
HGNCHGNC:10996NCBI Gene11001GeneCardsSLC27A2
Pharmacology
KEGGhsa:11001
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Long-chain fatty acid transport protein 2, how selective are they, and which programs against it are still in active trials?

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