Y+L amino acid transporter 2

BE0009872ProteinHumansSLC7A6

Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine... It is acted on by 1 drug in DrugBank.

Gene name
SLC7A6
UniProtKB entry
Q92536Swiss-Prot
Cellular location
Cell membrane
Residues / weight
515 residues · 56,827 Da
Also known as
Cationic amino acid transporter, y+ system · KIAA0245 · Solute carrier family 7 member 6 · y(+)L-type amino acid transporter 2 · y+LAT-2

Resolves to

Protein
UniProtQ92536UniProt nameYLAT2_HUMAN
Gene
HGNCHGNC:11064NCBI Gene9057GeneCardsSLC7A6
Pharmacology
KEGGhsa:9057
Structure
PDB9KY5PDB9LDR
Drugs

What you can answer from here — as of March 17, 2020

1DrugApproved to experimental, with action, bond type and pharmacological action
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12GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Y+L amino acid transporter 2, how selective are they, and which programs against it are still in active trials?

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