Receptor for retinol uptake STRA6

Details

Name

Receptor for retinol uptake STRA6

Kind

protein

Synonyms

• Retinol-binding protein receptor STRA6
• Stimulated by retinoic acid gene 6 protein homolog

Gene Name

STRA6

UniProtKB Entry

Q9BX79Swiss-Prot

Organism

Humans

NCBI Taxonomy ID

9606

Amino acid sequence

>lcl|BSEQ0052323|Receptor for retinol uptake STRA6
MSSQPAGNQTSPGATEDYSYGSWYIDEPQGGEELQPEGEVPSCHTSIPPGLYHACLASLS
ILVLLLLAMLVRRRQLWPDCVRGRPGLPSPVDFLAGDRPRAVPAAVFMVLLSSLCLLLPD
EDALPFLTLASAPSQDGKTEAPRGAWKILGLFYYAALYYPLAACATAGHTAAHLLGSTLS
WAHLGVQVWQRAECPQVPKIYKYYSLLASLPLLLGLGFLSLWYPVQLVRSFSRRTGAGSK
GLQSSYSEEYLRNLLCRKKLGSSYHTSKHGFLSWARVCLRHCIYTPQPGFHLPLKLVLSA
TLTGTAIYQVALLLLVGVVPTIQKVRAGVTTDVSYLLAGFGIVLSEDKQEVVELVKHHLW
ALEVCYISALVLSCLLTFLVLMRSLVTHRTNLRALHRGAALDLSPLHRSPHPSRQAIFCW
MSFSAYQTAFICLGLLVQQIIFFLGTTALAFLVLMPVLHGRNLLLFRSLESSWPFWLTLA
LAVILQNMAAHWVFLETHDGHPQLTNRRVLYAATFLLFPLNVLVGAMVATWRVLLSALYN
AIHLGQMDLSLLPPRAATLDPGYYTYRNFLKIEVSQSHPAMTAFCSLLLQAQSLLPRTMA
APQDSLRPGEEDEGMQLLQTKDSMAKGARPGASRGRARWGLAYTLLHNPTLQVFRKTALL
GANGAQP

Number of residues

667

Molecular Weight

73502.13

Theoretical pI

Not Available

GO Classification

Functions

retinal binding / retinol binding / retinol transmembrane transporter activity / signaling receptor activity

Processes

adrenal gland development / alveolar primary septum development / artery morphogenesis / blood vessel development / camera-type eye development / cognition / developmental growth / diaphragm development / digestive tract morphogenesis / ductus arteriosus closure / ear development / embryonic camera-type eye formation / embryonic digestive tract development / eyelid development in camera-type eye / face morphogenesis / feeding behavior / female genitalia development / head development / head morphogenesis / heart development / kidney development / learning / lung alveolus development / lung development / lung vasculature development / neuromuscular process / nose morphogenesis / paramesonephric duct development / positive regulation of behavior / pulmonary artery morphogenesis / pulmonary valve morphogenesis / retinol transport / smooth muscle tissue development / uterus morphogenesis / ventricular septum development / vocal learning

Components

plasma membrane / protein-containing complex

General Function

Functions as a retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:18316031, PubMed:22665496, PubMed:9452451). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (PubMed:18316031, PubMed:22665496). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin (PubMed:21368206, PubMed:22665496). Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid (PubMed:18316031). STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency (Probable). Does not transport retinoic acid (PubMed:18316031)

Specific Function

retinal binding

Pfam Domain Function

• RBP_receptor (PF14752)

Signal Regions

Not Available

Transmembrane Regions

51-71 101-121 145-165 169-189 206-226 296-316 368-388 423-443 474-494

Cellular Location

Cell membrane

Gene sequence

>lcl|BSEQ0052324|Receptor for retinol uptake STRA6 (STRA6)
ATGTCGTCCCAGCCAGCAGGGAACCAGACCTCCCCCGGGGCCACAGAGGACTACTCCTAT
GGCAGCTGGTACATCGATGAGCCCCAGGGGGGCGAGGAGCTCCAGCCAGAGGGGGAAGTG
CCCTCCTGCCACACCAGCATACCACCCGGCCTGTACCACGCCTGCCTGGCCTCGCTGTCA
ATCCTTGTGCTGCTGCTCCTGGCCATGCTGGTGAGGCGCCGCCAGCTCTGGCCTGACTGT
GTGCGTGGCAGGCCCGGCCTGCCCAGCCCTGTGGATTTCTTGGCTGGGGACAGGCCCCGG
GCAGTGCCTGCTGCTGTTTTCATGGTCCTCCTGAGCTCCCTGTGTTTGCTGCTCCCCGAC
GAGGACGCATTGCCCTTCCTGACTCTCGCCTCAGCACCCAGCCAAGATGGGAAAACTGAG
GCTCCAAGAGGGGCCTGGAAGATACTGGGACTGTTCTATTATGCTGCCCTCTACTACCCT
CTGGCTGCCTGTGCCACGGCTGGCCACACAGCTGCACACCTGCTCGGCAGCACGCTGTCC
TGGGCCCACCTTGGGGTCCAGGTCTGGCAGAGGGCAGAGTGTCCCCAGGTGCCCAAGATC
TACAAGTACTACTCCCTGCTGGCCTCCCTGCCTCTCCTGCTGGGCCTCGGATTCCTGAGC
CTTTGGTACCCTGTGCAGCTGGTGAGAAGCTTCAGCCGTAGGACAGGAGCAGGCTCCAAG
GGGCTGCAGAGCAGCTACTCTGAGGAATATCTGAGGAACCTCCTTTGCAGGAAGAAGCTG
GGAAGCAGCTACCACACCTCCAAGCATGGCTTCCTGTCCTGGGCCCGCGTCTGCTTGAGA
CACTGCATCTACACTCCACAGCCAGGATTCCATCTCCCGCTGAAGCTGGTGCTTTCAGCT
ACACTGACAGGGACGGCCATTTACCAGGTGGCCCTGCTGCTGCTGGTGGGCGTGGTACCC
ACTATCCAGAAGGTGAGGGCAGGGGTCACCACGGATGTCTCCTACCTGCTGGCCGGCTTT
GGAATCGTGCTCTCCGAGGACAAGCAGGAGGTGGTGGAGCTGGTGAAGCACCATCTGTGG
GCTCTGGAAGTGTGCTACATCTCAGCCTTGGTCTTGTCCTGCTTACTCACCTTCCTGGTC
CTGATGCGCTCACTGGTGACACACAGGACCAACCTTCGAGCTCTGCACCGAGGAGCTGCC
CTGGACTTGAGTCCCTTGCATCGGAGTCCCCATCCCTCCCGCCAAGCCATATTCTGTTGG
ATGAGCTTCAGTGCCTACCAGACAGCCTTTATCTGCCTTGGGCTCCTGGTGCAGCAGATC
ATCTTCTTCCTGGGAACCACGGCCCTGGCCTTCCTGGTGCTCATGCCTGTGCTCCATGGC
AGGAACCTCCTGCTCTTCCGTTCCCTGGAGTCCTCGTGGCCCTTCTGGCTGACTTTGGCC
CTGGCTGTGATCCTGCAGAACATGGCAGCCCATTGGGTCTTCCTGGAGACTCATGATGGA
CACCCACAGCTGACCAACCGGCGAGTGCTCTATGCAGCCACCTTTCTTCTCTTCCCCCTC
AATGTGCTGGTGGGTGCCATGGTGGCCACCTGGCGAGTGCTCCTCTCTGCCCTCTACAAC
GCCATCCACCTTGGCCAGATGGACCTCAGCCTGCTGCCACCGAGAGCCGCCACTCTCGAC
CCCGGCTACTACACGTACCGAAACTTCTTGAAGATTGAAGTCAGCCAGTCGCATCCAGCC
ATGACAGCCTTCTGCTCCCTGCTCCTGCAAGCGCAGAGCCTCCTACCCAGGACCATGGCA
GCCCCCCAGGACAGCCTCAGACCAGGGGAGGAAGACGAAGGGATGCAGCTGCTACAGACA
AAGGACTCCATGGCCAAGGGAGCTAGGCCCGGGGCCAGCCGCGGCAGGGCTCGCTGGGGT
CTGGCCTACACGCTGCTGCACAACCCAACCCTGCAGGTCTTCCGCAAGACGGCCCTGTTG
GGTGCCAATGGTGCCCAGCCCTGA

Chromosome Location

15

Locus

15q24.1

External Identifiers

Resource	Link
UniProtKB ID	Q9BX79
UniProtKB Entry Name	STRA6_HUMAN
GeneCard ID	STRA6
HGNC ID	HGNC:30650
KEGG ID	hsa:64220
NCBI Gene ID	64220

General References

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Associated Data

Drug Relations

Drug	Drug group	Pharmacological action?	Type	Actions	Details
Vitamin A	approved, nutraceutical, vet_approved	unknown	transporter	substrate	Details