Sphingosine 1-phosphate receptor 3

BE0009881ProteinHumansS1PR3

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). It is acted on by 2 drugs in DrugBank.

Gene name
S1PR3
UniProtKB entry
Q99500Swiss-Prot
Cellular location
Cell membrane
Residues / weight
378 residues · 42,250 Da
Also known as
C9orf108 · C9orf47 · EDG3 · Endothelial differentiation G protein-coupled receptor 3 · S1P receptor 3

Resolves to

Protein
UniProtQ99500UniProt nameS1PR3_HUMAN
Gene
HGNCHGNC:3167NCBI Gene1903GeneCardsS1PR3
Pharmacology
IUPHAR/GtoPdb277KEGGhsa:1903
Structure
PDB7C4SPDB7EW2PDB7EW3
Drugs

What you can answer from here — as of April 03, 2020

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sphingosine 1-phosphate receptor 3, how selective are they, and which programs against it are still in active trials?

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