Sphingosine 1-phosphate receptor 4

BE0009882ProteinHumansS1PR4

G protein-coupled receptor highly expressed in immune cells, where it regulates immune response and cytokine production. It is acted on by 3 drugs in DrugBank.

Gene name
S1PR4
UniProtKB entry
O95977Swiss-Prot
Cellular location
Cell membrane
Residues / weight
384 residues · 41,623 Da
Also known as
EDG6 · Endothelial differentiation G protein-coupled receptor 6 · S1P receptor 4 · S1P receptor Edg-6 · S1P4

Resolves to

Protein
UniProtO95977UniProt nameS1PR4_HUMAN
Gene
HGNCHGNC:3170NCBI Gene8698GeneCardsS1PR4
Pharmacology
IUPHAR/GtoPdb278KEGGhsa:8698
Structure
PDB2DCO
Drugs

What you can answer from here — as of April 03, 2020

3DrugsApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sphingosine 1-phosphate receptor 4, how selective are they, and which programs against it are still in active trials?

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