V-type proton ATPase subunit S1

BE0009939ProteinHumansATP6AP1

Accessory subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:28296633, PubMed:33065002).

Gene name
ATP6AP1
UniProtKB entry
Q15904Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
470 residues · 52,025 Da
Also known as
ATP6IP1 · ATP6S1 · Protein XAP-3 · V-ATPase Ac45 subunit · V-ATPase S1 accessory protein

Resolves to

Protein
UniProtQ15904UniProt nameVAS1_HUMAN
Gene
HGNCHGNC:868NCBI Gene537GeneCardsATP6AP1
Pharmacology
KEGGhsa:537
Structure
PDB6WLWPDB6WM2PDB6WM3

What you can answer from here — as of May 14, 2020

21GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which compounds in development act on V-type proton ATPase subunit S1, and which indications are they being tested in?

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