Tyrosine-protein phosphatase non-receptor type 12

BE0009940ProteinHumansPTPN12

Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). It is acted on by 1 drug in DrugBank.

Gene name
PTPN12
UniProtKB entry
Q05209Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
780 residues · 88,106 Da
Also known as
3.1.3.48 · Protein-tyrosine phosphatase G1 · PTP-PEST · PTPG1

Resolves to

Protein
UniProtQ05209UniProt namePTN12_HUMAN
Gene
HGNCHGNC:9645NCBI Gene5782GeneCardsPTPN12
Pharmacology
KEGGhsa:5782
Structure
PDB5HDEPDB5J8RPDB5O2P
Drugs

What you can answer from here — as of May 14, 2020

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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26+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein phosphatase non-receptor type 12, how selective are they, and which programs against it are still in active trials?

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