Tyrosine-protein phosphatase non-receptor type 6
Details
- Name
- Tyrosine-protein phosphatase non-receptor type 6
- Kind
- protein
- Synonyms
- 3.1.3.48
- HCP
- Hematopoietic cell protein-tyrosine phosphatase
- Protein-tyrosine phosphatase 1C
- Protein-tyrosine phosphatase SHP-1
- PTP-1C
- PTP1C
- SH-PTP1
- Gene Name
- PTPN6
- UniProtKB Entry
- P29350Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0052427|Tyrosine-protein phosphatase non-receptor type 6 MVRWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDF YDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQA ETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVTHIKVMCEGGRYTVGG LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD YINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKGRNK CVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSWPDH GVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDC DIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYGNIT YPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSKGSLKRK
- Number of residues
- 595
- Molecular Weight
- 67560.79
- Theoretical pI
- Not Available
- GO Classification
- Functionscell adhesion molecule binding / phosphorylation-dependent protein binding / phosphotyrosine residue binding / protein kinase binding / protein tyrosine phosphatase activity / SH2 domain binding / SH3 domain binding / transmembrane receptor protein tyrosine phosphatase activityProcessesB cell receptor signaling pathway / cell differentiation / cytokine-mediated signaling pathway / epididymis development / G protein-coupled receptor signaling pathway / hematopoietic progenitor cell differentiation / intracellular signal transduction / megakaryocyte development / natural killer cell mediated cytotoxicity / negative regulation of cell population proliferation / negative regulation of humoral immune response mediated by circulating immunoglobulin / negative regulation of interleukin-6 production / negative regulation of peptidyl-tyrosine phosphorylation / negative regulation of T cell proliferation / negative regulation of T cell receptor signaling pathway / negative regulation of tumor necrosis factor production / peptidyl-tyrosine dephosphorylation / peptidyl-tyrosine phosphorylation / platelet aggregation / platelet formation / positive regulation of cell adhesion mediated by integrin / positive regulation of cell population proliferation / protein dephosphorylation / regulation of apoptotic process / regulation of B cell differentiation / regulation of ERK1 and ERK2 cascade / regulation of G1/S transition of mitotic cell cycle / regulation of release of sequestered calcium ion into cytosol / regulation of type I interferon-mediated signaling pathway / T cell costimulationComponentsalpha-beta T cell receptor complex / cell-cell junction / cytoplasm / cytosol / extracellular exosome / extracellular region / membrane / nucleolus / nucleoplasm / nucleus / protein-containing complex / specific granule lumen / tertiary granule lumen
- General Function
- Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis
- Specific Function
- Cell adhesion molecule binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0052428|Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) ATGGTGAGGTGGTTTCACCGAGACCTCAGTGGGCTGGATGCAGAGACCCTGCTCAAGGGC CGAGGTGTCCACGGTAGCTTCCTGGCTCGGCCCAGTCGCAAGAACCAGGGTGACTTCTCG CTCTCCGTCAGGGTGGGGGATCAGGTGACCCATATTCGGATCCAGAACTCAGGGGATTTC TATGACCTGTATGGAGGGGAGAAGTTTGCGACTCTGACAGAGCTGGTGGAGTACTACACT CAGCAGCAGGGTGTCCTGCAGGACCGCGACGGCACCATCATCCACCTCAAGTACCCGCTG AACTGCTCCGATCCCACTAGTGAGAGGTGGTACCATGGCCACATGTCTGGCGGGCAGGCA GAGACGCTGCTGCAGGCCAAGGGCGAGCCCTGGACGTTTCTTGTGCGTGAGAGCCTCAGC CAGCCTGGAGACTTCGTGCTTTCTGTGCTCAGTGACCAGCCCAAGGCTGGCCCAGGCTCC CCGCTCAGGGTCACCCACATCAAGGTCATGTGCGAGGGTGGACGCTACACAGTGGGTGGT TTGGAGACCTTCGACAGCCTCACGGACCTGGTGGAGCATTTCAAGAAGACGGGGATTGAG GAGGCCTCAGGCGCCTTTGTCTACCTGCGGCAGCCGTACTATGCCACGAGGGTGAATGCG GCTGACATTGAGAACCGAGTGTTGGAACTGAACAAGAAGCAGGAGTCCGAGGATACAGCC AAGGCTGGCTTCTGGGAGGAGTTTGAGAGTTTGCAGAAGCAGGAGGTGAAGAACTTGCAC CAGCGTCTGGAAGGGCAGCGGCCAGAGAACAAGGGCAAGAACCGCTACAAGAACATTCTC CCCTTTGACCACAGCCGAGTGATCCTGCAGGGACGGGACAGTAACATCCCCGGGTCCGAC TACATCAATGCCAACTACATCAAGAACCAGCTGCTAGGCCCTGATGAGAACGCTAAGACC TACATCGCCAGCCAGGGTTGTCTGGAGGCCACGGTCAATGACTTCTGGCAGATGGCGTGG CAGGAGAACAGCCGTGTCATCGTCATGACCACCCGAGAGGTGGAGAAAGGCCGGAACAAA TGCGTCCCATACTGGCCCGAGGTGGGCATGCAGCGTGCTTATGGGCCCTACTCTGTGACC AACTGCGGGGAGCATGACACAACCGAATACAAACTCCGTACCTTACAGGTCTCCCCGCTG GACAATGGAGACCTGATTCGGGAGATCTGGCATTACCAGTACCTGAGCTGGCCCGACCAT GGGGTCCCCAGTGAGCCTGGGGGTGTCCTCAGCTTCCTGGACCAGATCAACCAGCGGCAG GAAAGTCTGCCTCACGCAGGGCCCATCATCGTGCACTGCAGCGCCGGCATCGGCCGCACA GGCACCATCATTGTCATCGACATGCTCATGGAGAACATCTCCACCAAGGGCCTGGACTGT GACATTGACATCCAGAAGACCATCCAGATGGTGCGGGCGCAGCGCTCGGGCATGGTGCAG ACGGAGGCGCAGTACAAGTTCATCTACGTGGCCATCGCCCAGTTCATTGAAACCACTAAG AAGAAGCTGGAGGTCCTGCAGTCGCAGAAGGGCCAGGAGTCGGAGTACGGGAACATCACC TATCCCCCAGCCATGAAGAATGCCCATGCCAAGGCCTCCCGCACCTCGTCCAAACACAAG GAGGATGTGTATGAGAACCTGCACACTAAGAACAAGAGGGAGGAGAAAGTGAAGAAGCAG CGGTCAGCAGACAAGGAGAAGAGCAAGGGTTCCCTCAAGAGGAAGTGA
- Chromosome Location
- 12
- Locus
- 12p13.31
- External Identifiers
Resource Link UniProtKB ID P29350 UniProtKB Entry Name PTN6_HUMAN GeneCard ID PTPN6 HGNC ID HGNC:9658 PDB ID(s) 1FPR, 1GWZ, 1X6C, 2B3O, 2RMX, 2YU7, 3PS5, 4GRY, 4GRZ, 4GS0, 4HJP, 4HJQ, 6SM5, 8YHI KEGG ID hsa:5777 NCBI Gene ID 5777 - General References
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Tiludronic acid approved, investigational, vet_approved unknown target inhibitor Details