Tyrosine-protein phosphatase non-receptor type 6

BE0009941ProteinHumansPTPN6

Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis (PubMed:14739280, PubMed:29925997). It is acted on by 1 drug in DrugBank.

Gene name
PTPN6
UniProtKB entry
P29350Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
595 residues · 67,561 Da
Also known as
3.1.3.48 · HCP · Hematopoietic cell protein-tyrosine phosphatase · Protein-tyrosine phosphatase 1C · Protein-tyrosine phosphatase SHP-1

Resolves to

Protein
UniProtP29350UniProt namePTN6_HUMAN
Gene
HGNCHGNC:9658NCBI Gene5777GeneCardsPTPN6
Pharmacology
KEGGhsa:5777
Structure
PDB1FPRPDB1GWZPDB1X6C
Drugs

What you can answer from here — as of May 14, 2020

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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38+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Tyrosine-protein phosphatase non-receptor type 6, how selective are they, and which programs against it are still in active trials?

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