V-type proton ATPase 116 kDa subunit a 1

BE0009946ProteinHumansATP6V0A1

Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that transports protons across cellular membranes.

Gene name
ATP6V0A1
UniProtKB entry
Q93050Swiss-Prot
Cellular location
Cytoplasmic vesicle, clathrin-coated vesicle membrane
Residues / weight
837 residues · 96,412 Da
Also known as
ATP6N1 · ATP6N1A · Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit · V-ATPase 116 kDa subunit a 1 · Vacuolar adenosine triphosphatase subunit Ac116

Resolves to

Protein
UniProtQ93050UniProt nameVPP1_HUMAN
Gene
HGNCHGNC:865NCBI Gene535GeneCardsATP6V0A1
Pharmacology
KEGGhsa:535
Structure
PDB6WLWPDB6WM2PDB6WM3

What you can answer from here — as of September 03, 2024

8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which compounds in development act on V-type proton ATPase 116 kDa subunit a 1, and which indications are they being tested in?

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