V-type proton ATPase 116 kDa subunit a 3

BE0009947ProteinHumansTCIRG1

Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).

Gene name
TCIRG1
UniProtKB entry
Q13488Swiss-Prot
Cellular location
Membrane
Residues / weight
830 residues · 92,967 Da
Also known as
ATP6N1C · ATP6V0A3 · OC-116 kDa · OC116 · Osteoclastic proton pump 116 kDa subunit

Resolves to

Protein
UniProtQ13488UniProt nameVPP3_HUMAN
Gene
HGNCHGNC:11647NCBI Gene10312GeneCardsTCIRG1
Pharmacology
KEGGhsa:10312

What you can answer from here — as of September 03, 2024

2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which compounds in development act on V-type proton ATPase 116 kDa subunit a 3, and which indications are they being tested in?

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