V-type proton ATPase subunit E 1

BE0009958ProteinHumansATP6V1E1

Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32001091, PubMed:33065002).

Gene name
ATP6V1E1
UniProtKB entry
P36543Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
226 residues · 26,145 Da
Also known as
ATP6E · ATP6E2 · p31 · V-ATPase 31 kDa subunit · V-ATPase subunit E 1

Resolves to

Protein
UniProtP36543UniProt nameVATE1_HUMAN
Gene
HGNCHGNC:857NCBI Gene529GeneCardsATP6V1E1
Pharmacology
KEGGhsa:529
Structure
PDB6WLZPDB6WM2PDB6WM3

What you can answer from here — as of May 15, 2020

6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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16+ReferencesStructured and connected to the statements they support
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Which compounds in development act on V-type proton ATPase subunit E 1, and which indications are they being tested in?

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