Caspase-4

BE0009964ProteinHumansCASP4

Inflammatory caspase that acts as the effector of the non-canonical inflammasome by mediating lipopolysaccharide (LPS)-induced pyroptosis (PubMed:25119034, PubMed:26375003, PubMed:32109412, PubMed:34671164, PubMed:37001519, PubMed:37993712, PubMed:37993714). It is acted on by 1 drug in DrugBank.

Gene name
CASP4
UniProtKB entry
P49662Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
377 residues · 43,262 Da
Also known as
3.4.22.57 · CASP-4 · ICE and Ced-3 homolog 2 · ICE(rel)-II · ICH-2

Resolves to

Protein
UniProtP49662UniProt nameCASP4_HUMAN
Gene
HGNCHGNC:1505NCBI Gene837GeneCardsCASP4
Pharmacology
IUPHAR/GtoPdb1620KEGGhsa:837
Structure
PDB6KMZPDB6NRYPDB7WR0
Drugs

What you can answer from here — as of May 15, 2020

1DrugApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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29+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Caspase-4, and which indications are they being tested in?

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