Cytochrome b-245 light chain

BE0009986ProteinHumansCYBA

Subunit of NADPH oxidase complexes that is required for the NADPH oxidase activity that generates, in various cell types, superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:15824103, PubMed:17140397, PubMed:38355798).

Gene name
CYBA
UniProtKB entry
P13498Swiss-Prot
Cellular location
Cell membrane
Residues / weight
195 residues · 21,012 Da
Also known as
Cytochrome b(558) alpha chain · Cytochrome b558 subunit alpha · Neutrophil cytochrome b 22 kDa polypeptide · p22 phagocyte B-cytochrome · p22-phox

Resolves to

Protein
UniProtP13498UniProt nameCY24A_HUMAN
Gene
HGNCHGNC:2577NCBI Gene1535GeneCardsCYBA
Pharmacology
KEGGhsa:1535
Structure
PDB1WLPPDB7U8GPDB7YXW

What you can answer from here — as of May 20, 2020

2Clinical trialsTrials of drugs acting on it, by phase and status
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47GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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23+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Cytochrome b-245 light chain, and which indications are they being tested in?

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